Search resultsRenal impairment and moderate alcohol consumption in the elderly. Results from the Italian longitudinal study on aging (ILSA)
Title
Renal impairment and moderate alcohol consumption in the elderly. Results from the Italian longitudinal study on aging (ILSA)
Publication type
Journal Article
Year of Publication
2011
Authors
Journal
Public Health Nutrition
Volume
14
Issue
11
Pagination
1907 - 1918
Date published
2011
ISBN
13689800 (ISSN)
Keywords
Aged, Aged, 80 and over, aging, Alcohol Drinking, alcoholic beverage, Alcoholic Beverages, article, blood, Cholesterol, Cohort study, creatinine, drinking, drinking behavior, drug effect, Female, fibrinogen, follow up, Follow-Up Studies, Glomerular Filtration Rate, glomerulus filtration rate, human, Humans, hypertension, incidence, Interview, Interviews as Topic, Italy, Kidney Failure, Logistic Models, Longitudinal Studies, longitudinal study, male, pathology, pathophysiology, prevalence, questionnaire, Questionnaires, Renal dysfunction, Renal Insufficiency, risk factor, Risk Factors, smoking, statistical model
Abstract
Objective The influence of moderate alcohol consumption on renal function is not clear in elderly people. The aim of the present study was to investigate the relationship between alcohol consumption and renal function, expressed as serum creatinine levels and glomerular filtration rates (GFR), in an elderly population. Design Perspective cohort study. Setting Population-based study on an elderly Italian population. Subjects A sample of 3404 Italian people (1619 women and 1785 men), aged 65-84 years, from the Italian Longitudinal Study on Aging (ILSA).Results Prevalence and cumulative risk of impaired renal function (defined as GFR ≤ 60 ml/min) were estimated by sex and alcohol consumption groups. Logistic regression analysis adjusting for confounders (age, education, smoking, BMI and medications) and intermediate factors (blood cholesterol and fibrinogen, systolic hypertension and diabetes) showed that alcohol consumption level was not significantly related to the prevalence of mild renal impairment in elderly women. In men, both prevalence and incidence results seemed to suggest an inverse linear relationship between moderate alcohol consumption and the risk of mild renal impairment. A U-shaped association was shown for women at the incidence phase, suggesting a higher risk of developing renal impairment for women who drink more than 24 g alcohol/d. Conclusions Our results suggest that, in accordance with the recommendations on alcohol consumption in the elderly, moderate quantities of alcohol are not injurious to renal function in elderly men.