Search resultsAlcohol consumption and 5-year onset of chronic kidney disease: The AusDiab study
Title
Alcohol consumption and 5-year onset of chronic kidney disease: The AusDiab study
Publication type
Journal Article
Year of Publication
2009
Authors
Journal
Nephrology Dialysis Transplantation
Volume
24
Issue
8
Pagination
2464 - 2472
Date published
2009
ISBN
09310509 (ISSN)
Keywords
Adult, age, Aged, albumin, albuminuria, alcohol, alcohol consumption, Alcohol Drinking, article, Australia, Case-Control Studies, chronic kidney disease, Cohort Studies, controlled study, creatinine, epidemiology, Estimated glomerular filtration rate, Female, Glomerular Filtration Rate, glomerulus filtration rate, human, Humans, hypertension, Kidney Failure, Chronic, kidney function, Longitudinal Studies, major clinical study, male, Middle Aged, priority journal, Prospective Studies, questionnaire, Risk Factors, sex difference, Survival Rate
Abstract
Background. Excessive alcohol consumption is a risk factor for hypertension and stroke; however, evidence for an association with chronic kidney disease is conflicting.Methods. A total of 6259 adults ≥25 years of age, without a history of alcohol dependence, participating in baseline (1999-2000) and follow-up (2004-2005) phases of an Australian population-representative study (AusDiab) were the subject of this analysis. Alcohol consumption status and volumefrequency were collected by standardized interviewer administered questionnaires and self-administered food frequency questionnaires. The outcomes were as follows: (i) 5-year decline in estimated glomerular filtration rate (eGFR) ≥10, with baseline eGFR ≥ 60 and final eGFR <60 mLmin1.73 m 2, and (ii) 5-year doubling of albumin to creatinine ratio (ACR) with final ACR ≥ 2.5 (males)≥ 3.5 (females) mgmmol, in the absence of albuminuria at baseline.Results. Self-identification as a moderate or heavy, versus light, drinker was associated with elevated risk of albuminuria in males and females <65 years of age (OR, 95 CI: males 1.87, 0.99-3.52; females 2.38, 1.37-4.14). Odds of de novo eGFR <60 mLmin1.73 m 2 were 0.34 (95 CI 0.22-0.59) and 0.68 (95 CI 0.36-1.27) in males and females, respectively, who were moderate-heavy drinkers. Alcohol intake of ≥30 gday was associated with an increased risk of albuminuria after adjustment for age, sex and baseline kidney function (OR = 1.59, 95 CI 1.07-2.36), but a reduced risk of eGFR <60 mLmin1.73 m 2 (OR = 0.59, 95 CI 0.37-0.95), compared with consumption of <10 gday.Conclusions. Moderate-heavy alcohol consumption may be an important modifiable risk factor for albuminuria in the general population. The natural history of alcohol-induced kidney damage and how this relates to markers of kidney function in the general population warrant further research.