Search resultsEffect of alcohol consumption on the liver detoxication capacity as measured by [13C2]aminopyrine and L-[1-13C]phenylalanine breath tests
Title
Effect of alcohol consumption on the liver detoxication capacity as measured by [13C2]aminopyrine and L-[1-13C]phenylalanine breath tests
Publication type
Journal Article
Year of Publication
2009
Authors
Journal
Isotopes in Environmental and Health Studies
Volume
45
Issue
3
Pagination
185 - 191
Date published
2009
ISBN
10256016 (ISSN)
Keywords
13C, 13CO2 breath tests, Adult, alcohol, aminophenazone, Aminopyrine, article, biology, breath analysis, Breath Tests, carbon, carbon dioxide, Carbon Isotopes, clinical trial, controlled clinical trial, controlled study, Cross-Over Studies, crossover procedure, detoxification, diagnostic agent, Diagnostic isotope application in medicine, dose response, Dose-Response Relationship, Drug, drug effect, Ethanol, Female, food consumption, health impact, human, Humans, L-[1-13C]phenylalanine, Liver, liver function, liver microsome, male, metabolism, Microsomes, Liver, phenylalanine, physiological response, randomized controlled trial, testing method, wine, Young Adult, [13C2]aminopyrine
Abstract
The aim of this study was to investigate the hepatic microsomal and cytosolic functions by using the 13CO2 breath test in healthy subjects either before or after consumption of red wine. Twelve adults received [13C2]aminopyrine and L-[1-13C]phenylalanine together with a standardised dinner. Expired air samples were taken over 6 h. After a wash-out period, the subjects consumed 0.4 ml ethanol per kg per day together with dinner over a 7.5-day period on average. Thereafter, 13C-tracer administration was repeated under identical conditions. The 13CO2 enrichments were measured by isotope ratio mass spectrometry. The mean cumulative percentage 13C-dose recovery after administration of [13C2]aminopyrine and L-[1-13C]phenylalanine either without or with red wine consumption amounted to 17.0±4.4 vs. 14.7±3.1% (p=0.170) and 14.0±2.8 vs. 11.5±3.9% (p=0.084), respectively. Moderate alcohol consumption does not induce significant short-term changes of the microsomal and the cytosolic function of the human liver in healthy subjects.