| Beer and Health database

Search results

Title

Diet and Alzheimer's disease

Publication type

Journal Article

Year of Publication

2007

Authors

Luchsinger, J.A., Noble, J.M., Scarmeas, N.

Journal

Current Neurology and Neuroscience Reports

Volume

Issue

Pagination

366 - 372

Date published

2007

ISBN

15284042 (ISSN)

Keywords

alcohol, alpha tocopherol, Alzheimer disease, amyloid beta protein, antioxidant, Antioxidants, apolipoprotein E, ascorbic acid, Brain, caloric intake, caloric restriction, carotene, carotenoid, clinical feature, clinical trial, correlational study, cyanocobalamin, diet restriction, diet supplementation, diet therapy, Dietary Fats, disease course, drug efficacy, fat intake, flavonoid, folic acid, food composition, food quality, Food, Formulated, genetic risk, glycemic load, heart disease, high risk patient, homocysteine, human, Humans, Mediterranean diet, neurofibrillary tangle, nonhuman, olive oil, oxidative stress, pathophysiology, placebo, protein blood level, pyridoxine, Randomized Controlled Trials as Topic, review, risk assessment, risk factor, risk reduction, secondary prevention, selegiline, trace element, treatment duration, Vitamins

Abstract

Alzheimer's disease (AD) is increasing in prevalence. There are no known preventive or curative measures. There is evidence that oxidative stress, homocysteine-related vitamins, fats, and alcohol have a role in the pathogenesis of AD. Some epidemiologic studies suggest that higher dietary intake of antioxidants, vitamins B6, B12, and folate, unsaturated fatty acids, and fish are related to a lower risk of AD, but reports are inconsistent. Modest to moderate alcohol intake, particularly wine, may be related to a lower risk of AD. The Mediterranean diet may also be related to lower AD risk. However, randomized clinical trials of supplements of vitamins E, B12, B6, and folate have shown no cognitive benefit, and randomized trials for other nutrients or diets in AD are not available. The existing evidence does not support the recommendation of specific supplements, foods, or diets for the prevention of AD. Copyright

DOI

https://dx.doi.org/10.1007/s11910-007-0057-8

Search results