Search resultsNeuroprotective effect of acute ethanol administration in cerebral ischemia through inhibiting adenosine phosphate-activated protein kinase (AMPK) pathway
Title
Neuroprotective effect of acute ethanol administration in cerebral ischemia through inhibiting adenosine phosphate-activated protein kinase (AMPK) pathway
Publication type
Journal Article
Year of Publication
2012
Authors
Journal
Medical Hypotheses
Volume
79
Issue
5
Pagination
595 - 597
Date published
2012
ISBN
03069877 (ISSN)
Keywords
Adenylate Kinase, alcohol, alcohol consumption, apoptosis, article, brain infarction size, brain ischemia, cerebrovascular accident, enzyme inhibition, enzyme phosphorylation, Ethanol, fibrinolysis, glioma cell, glucose, glucose blood level, glucose utilization, glycolysis, human, Humans, hydroxymethylglutaryl coenzyme A reductase kinase, hyperglycemia, hypertension, insulin blood level, insulin release, insulin sensitivity, insulin treatment, mortality, nerve cell necrosis, neuroprotection, Neuroprotective Agents, nonhuman, thrombocyte aggregation
Abstract
Various epidemiologic studies in recent years have indicated that light/moderate alcohol consumers have lower risks of nerve degenerative disease, suggesting that ethanol have neuroprotective effect. Ethanol is known to be involved in many signaling pathway, such as AMPK, protein kinase B/AKT and protein kinase C. Recently, some researches found that acute ethanol have neuroprotective effect, the mechanisms underlying it (acute ethanol-induced) are not completely understood. Integrating existing related research, it will be interesting to explore whether inhibit AMPK levels after acute ethanol administration is one of the mechanisms for neuroprotective effect.