Neuroprotective effect of acute ethanol administration in cerebral ischemia through inhibiting adenosine phosphate-activated protein kinase (AMPK) pathway

Title
Neuroprotective effect of acute ethanol administration in cerebral ischemia through inhibiting adenosine phosphate-activated protein kinase (AMPK) pathway
Publication type
Journal Article
Year of Publication
2012
Journal
Medical Hypotheses
Volume
79
Issue
5
Pagination
595 - 597
Date published
2012
ISBN
03069877 (ISSN)
Abstract

Various epidemiologic studies in recent years have indicated that light/moderate alcohol consumers have lower risks of nerve degenerative disease, suggesting that ethanol have neuroprotective effect. Ethanol is known to be involved in many signaling pathway, such as AMPK, protein kinase B/AKT and protein kinase C. Recently, some researches found that acute ethanol have neuroprotective effect, the mechanisms underlying it (acute ethanol-induced) are not completely understood. Integrating existing related research, it will be interesting to explore whether inhibit AMPK levels after acute ethanol administration is one of the mechanisms for neuroprotective effect.