Search resultsLight to moderate alcohol consumption is associated with lower frequency of hypertransaminasemia
Title
Light to moderate alcohol consumption is associated with lower frequency of hypertransaminasemia
Publication type
Journal Article
Year of Publication
2007
Authors
Journal
American Journal of Gastroenterology
Volume
102
Issue
9
Pagination
1912 - 1919
Date published
2007
ISBN
00029270 (ISSN)
Keywords
Adult, alanine aminotransferase, Alanine Transaminase, alcohol, alcohol consumption, Alcohol Drinking, alcohol liver disease, article, aspartate aminotransferase, Aspartate Aminotransferases, Body Mass Index, chronic liver disease, cohort analysis, controlled study, cross-sectional study, disease association, fatty liver, follow up, groups by age, hepatitis B, hepatitis C, human, Humans, hypertransaminasemia, Japanese, longitudinal study, major clinical study, male, Middle Aged, multivariate logistic regression analysis, priority journal, statistical significance, workplace
Abstract
OBJECTIVES: The effect of light to moderate alcohol consumption on the liver is controversial. To determine the association between light to moderate alcohol consumption and frequency of hypertransaminasemia, a cross-sectional and a subsequent longitudinal cohort study were conducted using annual health checkup data at a Japanese workplace. METHODS: We analyzed 1,177 male subjects (age 20-59) without HCV or HBV infection or other chronic liver diseases. To determine the association between alcohol consumption (none or minimal <70 g/wk, light ≥70 g and <140 g/wk, moderate ≥140 g and <280 g/wk, excessive ≥280 g/wk) and hypertransaminasemia, we performed multiple logistic regressions. We then followed 326 subjects without a history of fatty liver or hypertransaminasemia up to 5 years for incidental hypertransaminasemia and performed Cox proportional hazard regressions. RESULTS: Excess alcohol consumption was associated with increased odds of hypertransaminasemia (adjusted odds ratio [AOR ] versus none or minimal consumption 1.4 [1.1-1.93 ], P = 0.023). There was significant interaction between age group and alcohol consumption (P < 0.01). In the younger group, moderate consumption was associated with decreased odds (AOR 0.5 [0.3-0.9 ], P = 0.032), while in the older group, light consumption was associated with decreased odds (AOR 0.6 [0.4-1.0 ], P = 0.036) and excess consumption was associated with increased odds (AOR 1.6 [1.1-2.3 ], P = 0.014) of hypertransaminasemia. During follow-up, moderate consumption was associated with decreased incidence of hypertransaminasemia versus none or minimal consumption (adjusted hazard ratio 0.4 [0.1-0.9 ], P = 0.02). CONCLUSION: Light to moderate alcohol consumption may protect against the development of hypertransaminasemia among male subjects without other liver conditions. Further studies are required before recommending light to moderate alcohol consumption.