Search resultsAlcohol drinking patterns and the risk of fatty liver in Japanese men
Title
Alcohol drinking patterns and the risk of fatty liver in Japanese men
Publication type
Journal Article
Year of Publication
2011
Authors
Journal
Journal of Gastroenterology
Volume
46
Issue
4
Pagination
519 - 528
Date published
2011
ISBN
09441174 (ISSN)
Keywords
Adult, Aged, alanine aminotransferase, alcohol consumption, Alcohol Drinking, article, Asian Continental Ancestry Group, aspartate aminotransferase, body composition, body mass, body weight, Cross-Sectional Studies, diabetes mellitus, drinking behavior, dyslipidemia, echography, Ethanol, fatty liver, gamma glutamyltransferase, high density lipoprotein cholesterol, human, Humans, hypertension, Japan, Japanese, Logistic Models, major clinical study, male, Metabolic syndrome, Middle Aged, Multivariate Analysis, nonalcoholic fatty liver, Nonalcoholic fatty liver disease, obesity, prediction, prevalence, priority journal, questionnaire, Questionnaires, risk assessment, smoking, triacylglycerol
Abstract
Background: Alcohol is considered to be a major cause of fatty liver (FL). In contrast, however, recent investigations have suggested that moderate alcohol consumption is protective against FL. To clarify the role of alcohol consumption in FL development, we examined the association between drinking patterns and FL prevalence. Methods: We enrolled 9,886 male participants at regular medical health checks. Each subject's history of alcohol consumption was determined by questionnaire. The subjects were classified according to alcohol consumption as non-, light, moderate, and heavy drinkers (0, <20, 20-59, and ≥60 g/day, respectively). FL was defined by ultrasonography. Independent predictors of FL were determined by logistic regression analysis. Results: The prevalence of FL displayed a "U-shaped curve" across the categories of daily alcohol consumption (non-, 44.7%; light, 39.3%; moderate, 35.9%; heavy drinkers, 40.1%; P < 0.001). The prevalence of FL was associated positively with body mass index and other obesity-related diseases and inversely with alcohol consumption (light, odds ratio [OR] 0.71, 95% confidence interval [CI] 0.59-0.86; moderate, OR 0.55, CI 0.45-0.67; heavy, OR 0.44, CI 0.32-0.62) as determined by multivariate analysis after adjusting for potential confounding variables. In addition, examination of drinking patterns (frequency and volume) revealed that the prevalence of FL was inversely associated with the frequency of alcohol consumption (≥21 days/month) (OR 0.62, CI 0.53-0.71) but not with the volume of alcohol consumed. Conclusions: Our observations suggest that alcohol consumption plays a protective role against FL in men, and consistent alcohol consumption may contribute to this favorable effect.